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Tramadol can be a synthetic creation that was created to offer the structural part of morphine that gives it its pain-killing activity. But in 2013, M. De Waard and lots of colleagues in France, Cameroon, and Switzerland reported its occurrence within the Cameroonian pincushion tree (Nauclea latifolia). Although De Waard’s experiments took pains to rule out contamination of the plants by synthetic tramadol, in September 2014, however, research by M. Spiteller and coauthors in Germany and Cameroon indicated that tramadol within the trees could be the response to human contamination, more than likely because natives in northern Cameroon administer the drug to working farm animals so that they tire less easily. The authors think that the animals’ urine contaminates the soil where the trees grow.

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